Insight from inside the system.

Join Keith J. Figlioli (LRVHealth) and Sri Narasimhan (CVS Health) this Thursday for an expert briefing hosted by Health Tech Nerds and moderated by Kevin O'Leary. Together, they'll explore how health systems and payers should be thinking about governing the coming wave of AI agents. The discussion is a follow-up to their recent Health Tech Nerds article, “Who Will Manage Healthcare's AI Explosion?” The expert briefing is an opportunity to ask questions and dive deeper into the governance, oversight, and accountability challenges that come with managing AI agents at scale. Register for the Expert Briefing: https://lnkd.in/gVfEXEsn Read “Who Will Manage Healthcare's AI Explosion?”: https://lnkd.in/eSYVRMuP

AI is moving faster than any one organization can keep up with, making it more important than ever for leaders to come together, share experiences, and learn from one another. The AI Leadership Forum was created to provide that space: an invitation-only gathering of executives from health systems and payer organizations, intentionally kept intimate to foster candid conversations, peer learning, and the open exchange of ideas. Many participants shared that one of the most valuable aspects of the Forum was the opportunity to connect with peers facing similar challenges and gain reassurance that the questions they're navigating are shared across the industry, while also leaving with new ideas that challenged and refined their thinking. We were also joined by leading entrepreneurs whose companies are tackling many of the challenges health systems and payers are working to solve, bringing an important perspective to the discussion and helping connect emerging companies with the needs of healthcare organizations. We are grateful to the speakers, entrepreneurs, guests, and industry leaders who participated and contributed to the conversation. Special thanks to Sutter Health for hosting us at the Innovation Center in San Francisco and to our partners at CVS Health Ventures, GV (Google Ventures), and Vizient for helping make this gathering possible.

Who will manage healthcare's AI agent explosion? For health system and payer executives, the key question is no longer if AI agents will permeate their organizations, but how to effectively manage and govern them when they do. A new article by Keith J. Figlioli & Lise Courtney D'Amico of LRVHealth and Sri Narasimhan & Alan Rosa of CVS Health, published in Health Tech Nerds, examines how healthcare organizations should be preparing for this next phase of AI adoption. They explore: - Why the biggest challenge of AI agent adoption may not be the technology itself, but the operational complexity that comes with managing it - What an emerging agent control layer could look like and who is best positioned to deliver it - Principles for building a governance model that can scale with AI agent proliferation without slowing innovation - Practical steps health systems and payers can take today to prepare for the next two to five years Read the full article: https://lnkd.in/eSYVRMuP The conversation continues on Oct 22: Health Tech Nerds is hosting a live Q&A with Keith J. Figlioli and Sri Narasimhan on October 22 at 12:00pm ET to discuss these ideas and answer questions from the healthcare community. Register here: https://luma.com/ffn36zd8

We're excited to welcome Erica Landesberg to LRVHealth as our new Director of Value Creation. Erica will lead the continued expansion of LRVHealth's value creation function, partnering with our portfolio companies and strategic network to help accelerate growth, drive strategic execution, and create meaningful opportunities for impact across our network. Erica brings experience across healthcare strategy, operations, and transformation, working with both growing healthcare companies and established health systems. Most recently, she served as Vice President of Analytics and Strategic Initiatives at Access TeleCare, where she led analytics, strategy, and operational improvement initiatives across the organization. Prior to Access TeleCare, she was an Engagement Manager at McKinsey & Company, advising health systems on strategy and operational transformation. Erica joins our growing team in New York City as we continue to expand our presence and deepen our relationships across the city’s healthcare community. Welcome to the team, Erica!

Most conversations about health system transformation focus on things like AI, new treatments and expanded access, but they rarely focus on the financing required to support these changes. Where does that capital come from? For the latest episode of the #HealthcareIsHard podcast, Keith J. Figlioli spoke with Lisa Goldstein, managing director of treasury and capital markets at Kaufman Hall, about the financial mechanics that shape a health system’s ability to grow, manage risk and invest in care. A few highlights: → Credit ratings are not report cards. More than letter grades, they signal investor confidence in a health system’s ability to repay debt, and can affect its access to capital. → Mission requires margin. Not-for-profit health systems still need durable margins and cash reserves to sustain operations, invest in their communities and finance future growth. As Lisa says, “not-for-profit doesn’t mean pro-deficit.” → Every priority has a financial tradeoff. CFOs have the difficult job of weighing clinical needs, operational pressures and long-term investments against the resources available. → Innovation will not make healthcare less capital intensive. New clinical capabilities, an aging population and aging facilities will keep investment needs high for the foreseeable future. Catch the full episode here: https://lnkd.in/dCk_yJwT

Earlier this week, we joined our partners at Aetna, a CVS Health Company and CVS Health Ventures in bringing together leaders for the Medicaid Innovation Forum. Over two days, we came together with Aetna Better Health market CEOs from across the country and some of the most innovative companies building solutions for the Medicaid market. While these leaders approach challenges from different perspectives, they share the same goal of improving care, outcomes, and experiences for Medicaid populations. What made the forum so impactful was the opportunity for these groups to spend meaningful time together. Too often, healthcare leaders and innovators are working toward the same objectives without having the space to openly discuss the challenges they're facing, the lessons they're learning, and the solutions they're developing. The feedback we received reinforced just how valuable these opportunities to connect can be: - "I can't think of anything I've participated in over the years that's provided more value." - "It was one of the most valuable experiences I have had since I founded my company." - "What a privilege being invited to such a curated, inspiring, and informative event." We heard similar sentiments from Aetna Better Health CEOs, many of whom shared how different this experience was from traditional events and how excited they were to continue conversations with the innovators they met. Thank you to Katerina Guerraz, the Aetna team, and CVS Health Ventures for being exceptional partners. We look forward to creating more opportunities for innovators and healthcare leaders to learn from one another and forge new partnerships.

Another exciting announcement from the LRVHealth portfolio: Reimagine Care has been acquired by Cureety. When we invested in Reimagine Care, we saw the opportunity to extend expert oncology care beyond the clinic. Through its AI-enabled virtual care platform and oncology-specialized teams, Reimagine Care has helped expand access to care, reduce provider burden, and improve the patient experience throughout the care journey. This acquisition represents an important step toward more continuous precision oncology care, where monitoring, engagement, and clinical support are tailored to each patient’s therapy, risks, and needs. Together, Cureety and Reimagine Care have an opportunity to advance this model across health systems, expanding clinical capacity while enabling more personalized, continuous support for patients. As Reimagine Care CEO Dan Nardi shared, “Oncology is entering a period where sophistication of the care model has to catch up with sophistication of the treatment. Patients should be able to receive highly personalized support wherever they are, whenever they need it, while their oncologists remain at the center of their care.” Congratulations to Dan Nardi and the entire Reimagine Care team on this tremendous achievement! We’re excited to see this next chapter further advance precision oncology care. Read the full announcement: https://lnkd.in/gvX7vD3Q

CVS Health operates one of healthcare’s largest consumer platforms. With businesses spanning insurance, pharmacy benefits, retail pharmacy, care delivery and digital channels, it has a unique view into how people interact with the healthcare system – and where fragmentation creates friction. On the latest episode of the #HealthcareIsHard podcast, Keith J. Figlioli talked to Sri Narasimhan, who leads enterprise customer experience, insights and innovation at CVS, about the massive opportunity for using AI to improve the consumer experience. A few themes from the conversation: → Healthcare has to stop benchmarking itself against itself. Consumers compare their healthcare experiences with the simple, intuitive interactions they have everywhere else. That’s the new baseline the industry has to meet and exceed. → AI won’t replace relationship. As AI tools become more useful, consumers will increasingly use them for quick answers about symptoms, diagnoses and side effects. But Sri believes trusted provider relationships will remain critical when the stakes are high. → Agentic twins could transform consumer research. CVS Health has built digital twins of roughly 150,000 consumers that can simulate how people may respond to messages, choices and new scenarios. It gives CVS the ability to test ideas in minutes rather than relying solely on focus groups, panels or small pilots. Listen to the full conversation: https://lnkd.in/gfyvUQ8s #HealthcareAI #ConsumerHealth #DigitalHealth #HealthcareInnovation

We are excited to share that LRVHealth portfolio company Humata Health is joining forces with R1 RCM! When we co-led Humata's funding round in June 2024, we believed in the team's vision of transforming one of healthcare's most frustrating administrative challenges: prior authorization. Their goal was to create a frictionless prior authorization experience for providers and payers so patients can get the care they need without unnecessary delays. Since then, Humata has partnered with many of our Strategic Limited Partners and demonstrated the impact AI can have on streamlining prior authorization. Their solution has helped providers achieve up to a 96% first-pass approval rate while reducing write-offs by 30%, rescheduled appointments by 83%, and staff touches by 45%. This next chapter with R1 is an exciting opportunity to scale that impact even further. By joining R1, Humata will integrate its AI-powered prior authorization capabilities into R1’s Phare OS to build a complete, end-to-end revenue operating system, helping automate and connect critical workflows across the revenue cycle at scale. Congratulations to Jeremy Friese, MD and the entire Humata Health team on this incredible achievement. We are proud to have partnered with you on this journey so far and believe this acquisition marks an important step toward a more automated and efficient revenue cycle. Read the full press release: https://lnkd.in/giQmP6ex Read the blog from Jeremy Friese, MD: https://lnkd.in/eADbtUmg

Congratulations to LRVHealth portfolio company Main Street Health on being named #1 on the 2026 #Inc5000 list of America’s fastest-growing private companies. That growth reflects the meaningful impact Main Street Health is having in rural communities across the country. The company has delivered strong clinical outcomes, including a 51% improvement in quality Star scores, a 53% reduction in hospital readmissions, and an 11% reduction in medical costs. As Main Street Health President Bennett Graham shared, "The growth we have achieved over the past three years comes from our focus on effective partnerships with rural providers and the value we place on community and building trusted relationships. We are impacting the lives of rural Americans daily." Congratulations to the entire Main Street Health team on this well-deserved recognition! We’re proud to partner with you and excited to continue supporting the team as you expand your impact. https://lnkd.in/eBGHyVTH

Among the many workflows in healthcare being reshaped by AI, revenue cycle management is experiencing some of the most rapid transformation. More than 80% of healthcare leaders consider AI integral to RCM operations, and more than 60% have already deployed AI-powered solutions to improve claims processing, streamline denials management, and optimize revenue integrity. While payers have been slower to react, they are increasingly investing in technology to support their operations and respond to providers. This was the focus of one of the panel discussions at our 2026 Annual Meeting: “Who Ultimately Wins the AI Bot War in RCM: Providers, Payers, or Both?” Moderated by Jeremy Friese, MD of Humata Health, the panel featured Katerina Guerraz of Aetna, a CVS Health Company and Jeff Mincher of Texas Health Resources. The discussion explored how both providers and payers are applying AI across revenue cycle and claims processing workflows while recognizing that today's processes often create unnecessary friction for everyone involved. The group discussed how payers and providers can align on a shared vision around using technology and AI to create frictionless experiences for patients and providers, cut down on claims rework, embed transparency, and build toward real-time payments driven by interoperability. Read the full recap of our 2026 Annual Meeting: https://lnkd.in/gK5RfUWa

As physician employment patterns continue to evolve, health systems, corporate and private equity-backed platforms, and independent providers are all competing to attract and retain clinicians while responding to changing market dynamics. During our 2026 Annual Meeting, we dedicated a panel to exploring competing clinical ownership models and the market impacts. The panel, moderated by Alex Jahangir of Vanderbilt University Medical Center, featured Katherine Abraham Evans of Cardiovascular Associates of America - CVAUSA, Dan Roth of Trinity Health, and Lee Williams of DENT Neurologic Institute. The discussion examined how physician employment decisions increasingly reflect a combination of financial considerations, professional autonomy, organizational culture, and work-life expectations. Panelists explored how organizations can build sustainable models for clinical ownership and empowerment, while remaining adaptable to changing workforce preferences, regulatory pressures, and evolving models of care delivery. Read the full recap of our 2026 Annual Meeting: https://lnkd.in/gK5RfUWa

On the latest episode of the #HealthcareIsHard podcast, Keith J. Figlioli talked to J.D. Whitlock, CIO at Dayton Children's Hospital, about how smaller health systems can still deliver world-class care while navigating the realities of pediatrics, technology, and innovation. A few themes from the conversation: → Pediatrics is different. Children’s hospitals have unique demands because their patients are not just smaller adults. Digital tools have to account for parents and guardians, adolescent privacy, state-specific confidentiality laws, and family expectations for digital-first communication. → Innovation has to scale. Dayton Children’s cannot simply pilot technology because it is interesting. J.D. describes a disciplined approach in which pilots are treated as phase-one implementations, with the expectation that the organization has already studied the evidence and believes the solution can work. → AI value starts with core systems. Despite the flood of new AI companies entering healthcare, J.D. believes much of the near-term value will come from the core systems health organizations already use. Point solutions can still earn a place, but they need mature integrations and evidence of ROI. → ROI must match the use case. Not every technology investment has the same kind of return. Some need to show hard savings, while others are about improving the clinician experience, supporting retention, or making care delivery work better. Listen here: https://lnkd.in/g6cyZHvV

If there’s one thing that’s defined the last year in healthcare technology, it’s the speed. AI has moved from pilot programs and boardroom decks to real deployment inside healthcare organizations, and it’s happened faster than most of us predicted. The question is no longer whether to adopt AI, but how to sequence it, who to partner with, and how to separate signal from noise in a market that has never been louder. To help make sense of all this, we dedicated two sessions at our Annual Meeting last month to these questions. We kicked off the event with an opening keynote featuring John Brownstein of Boston Children's Hospital, Dominic King, MD PhD of Microsoft AI, and Syed Mohiuddin of Anthropic on the evolving AI landscape. The following morning, Brian Anderson, MD of Coalition for Health AI (CHAI) and Lee Schwamm, MD of Yale New Haven Health joined us for a breakfast discussion on the practical implementation of AI inside healthcare organizations. A few takeaways from these sessions included: The Evolving AI Landscape - AI is advancing at an exponential pace, requiring a reset in how healthcare leaders think and plan.  - The role of AI in healthcare is shifting from narrow tools to multimodal, general-purpose clinical collaborators.  - AI will ultimately expand workforce capacity via “virtual coworkers.” Teams will increasingly be structured around both humans and AI agents. - Consumer AI is emerging as the front door to healthcare, creating both opportunity and responsibility. - Sustainable advantage will come from workflow integration, not proprietary data. While data moats erode over time, deeply embedded, trusted workflows within clinical and operational systems will define defensibility. The Practical Implementation of AI - The primary barrier to scaling AI is unclear and inconsistently defined ROI. Most pilots stall because organizations fail to define success upfront. - AI adoption should follow a clinical evidence-building mindset, not a traditional IT rollout.  - Human-in-the-loop models will outperform fully autonomous systems in the near term. AI is powerful but potentially harmful if misapplied, so it requires human supervision, especially in clinical contexts. - Labor and trust dynamics must be managed carefully. AI will reshape jobs rather than simply eliminate them, and maintaining public trust is critical, especially in a major employment sector. If you’re an entrepreneur thinking about these challenges and opportunities in healthcare, reach out to our team. We’d love to connect.

On the latest episode of the #HealthcareIsHard podcast, Laura Wilt, EVP and Chief Digital Officer at Sutter Health, joined Keith J. Figlioli for a conversation about what it really takes to lead digital change at scale. Their conversation focused on a challenge many health systems are navigating right now. The fact that technology is advancing exponentially, but the ability to adopt that change remains much more linear. Laura shared a practical perspective on how to close that gap – from designing pilots that can scale, to using principle-based decision-making, and preparing for a future shaped by an AI-informed consumer. This is a thoughtful discussion for leaders thinking about AI, digital strategy, workflow change, and the future of connected care. Catch the full episode at https://lnkd.in/gZt8yB8m #DigitalHealth #HealthcareAI #HealthSystems #HealthcareLeadership

Few advances in modern medicine have generated as much promise as cell and gene therapies (CGTs). Yet despite remarkable clinical progress, most eligible patients still never receive these therapies. Today, only an estimated 20-30% of patients who are clinically eligible for treatments such as CAR-T ultimately access them. The bottleneck is no longer science; it is infrastructure. The healthcare system was optimized to deliver chronic, repeatable therapies, not highly personalized, operationally complex, multi-million-dollar treatments that require coordination across manufacturers, providers, logistics networks, and payers. In their latest article, Josh Flum, Karen Au Yeung, and Lise Courtney D'Amico explore: - Where we see bottlenecks across the CGT ecosystem - How gene therapies, cell therapies, and cell-based gene therapies each create distinct operational, financial, and care delivery challenges - The evolving innovation landscape and the emerging orchestration layer needed to support CGT delivery at scale There are still a lot of open questions around how the market will evolve, but what is becoming increasingly clear is that CGT is not just a new therapeutic category but a new healthcare infrastructure category. Thank you to the Oliver Wyman team for their thought partnership in developing this article. Read the full piece: https://lnkd.in/guE7ZUAB If you are innovating in this space, we would love to connect. Reach out to us here: https://lnkd.in/gN3833uq

Investing With Healthcare. These three words capture a belief that has guided LRVHealth for years: meaningful change in healthcare requires more than capital. It requires deep collaboration with the organizations delivering and paying for care, and with the entrepreneurs building what's next. Last week brought that belief to life in two important ways. We launched a new website that better reflects our approach and the relationships that make it possible. We also welcomed leaders from across our network to Boston for the 2026 LRVHealth Annual Meeting. Throughout our Annual Meeting, executives from our Strategic Limited Partner network of leading healthcare organizations, CEOs from our portfolio companies, and our executive advisors came together to discuss some of healthcare's most important challenges and opportunities. More importantly, they shared perspectives, built new connections, and strengthened the relationships that help drive innovation across the industry. Those interactions and the collaboration among these groups are at the heart of what we do. We invest with founders changing healthcare and with the organizations helping drive that change forward. By staying deeply engaged with both sides and fostering meaningful connections across our network, we help create opportunities that accelerate innovation and real-world impact. Thank you to everyone who joined us last week and contributed to the conversations! Here are photos of a few of our favorite moments throughout the event. To learn more about our network, model, and team, explore our new website: https://lrvhealth.com/

Healthcare leadership has always been challenging. But Tom Priselac – who served as CEO at Cedars-Sinai for 30 years – agrees that it’s never been harder than it is today. In our latest episode of the #HealthcareIsHard podcast, Tom reflects on nearly 50 years helping to build Cedars-Sinai into a major academic health system and applies some of the lessons he learned to the challenges healthcare leaders face today. Some takeaways from Tom’s conversation with Keith J. Figlioli: → Culture is everything: In complex organizations, leadership isn’t just strategy. It’s values, emotional intelligence, and creating a shared sense of mission around patient care. → Change has limits: Healthcare leaders are under pressure to move fast, but organizations can only absorb so much change at once. Some of the biggest leadership mistakes happen when transformation outpaces people. → Innovation alone won’t solve healthcare’s biggest problems: Even amid breakthroughs in AI, genomics, and precision medicine, cost and access remain the industry’s most urgent unresolved challenges. → Leadership fundamentals still matter: The environment may be more complex than ever, but the core responsibilities of leadership—building trust, aligning teams, and guiding organizations through change—haven’t changed. Listen here: https://lnkd.in/eq5vHAUW #HealthcareLeadership #HealthSystems #HealthcareInnovation #DigitalHealth #HealthcareManagement #HealthcareIsHard

Boston founders: Microsoft for Startups, Flare Capital Partners, and LRVHealth are co-hosting a Healthcare + AI gathering on Tuesday, June 9, bringing together local founders, investors, and operators. Keith J. Figlioli will be on the panel, alongside Parth Desai, Sally Ann Frank, and Ranya Habash, MD. The discussion will center on what’s actually working in early-stage healthcare AI today: - How teams are getting real traction - What “enterprise readiness” looks like in practice - How investors are evaluating companies right now If you’re building in healthcare or AI in Boston, join us for an evening of thoughtful conversation and connection. 📍 Lifted Restaurant, Omni Boston Seaport 🗓️ June 9 | 6–9 PM 🔗 Register here: https://lnkd.in/eRD6eUd8

Healthcare Innovation recently sat down with Keith J. Figlioli for a conversation about where healthcare AI procurement is headed. In an interview with David Raths, Keith drills into a point that’s becoming more important every day – the fact that health systems and payers cannot keep buying AI one tool at a time. Instead, they need to start thinking architecturally across core enterprise platforms, foundation model platforms, and specialized use cases. This conversation builds on an article Keith published last month in Fierce Healthcare, where he laid out why AI can no longer be treated as an application decision and needs to become an enterprise architecture decision. Read the Healthcare Innovation interview: https://lnkd.in/evJeQ9NK Read Keith’s earlier Fierce Healthcare piece: https://lnkd.in/e62-KE4K

We’re looking forward to the Barclays NFP Healthcare Investor Conference this week! LRVHealth Managing Partner Josh Flum will join Jigar Thakkar (CEO, Longitude Rx), Eric Huckins (Chief Growth Officer, Lumicera Health Services), and moderator Andrew Mok, CFA (Director of Equity Research, Barclays) for a panel discussing the key trends shaping the pharmaceutical landscape for not-for-profit health systems. Panelists will explore evolving drug pricing dynamics, pharmacy benefit strategies, and innovative partnership models—and what these developments mean for cost management, access, and long-term financial sustainability. If you’ll be at the conference, join the discussion on Wednesday, May 20 at 8am ET.

We're hiring! LRVHealth is looking for a Director, Value Creation to help scale the impact of our Strategic Limited Partner (SLP) network and accelerate growth across our portfolio. In this role, you will: - Amplify the impact of our strategic LP network – strengthening senior healthcare relationships and driving measurable strategic value to our SLP partnerships - Help build and execute LRV’s Portfolio GTM & Growth function, working hands-on with portfolio companies to unlock growth opportunities - Turn market trends and network insights into forward-looking perspectives that fuel our investment theses, network intelligence, and thought leadership We’re looking for an action-oriented, intellectually curious builder eager to help bridge healthcare innovation into real-world impact. Full job description: https://lnkd.in/e8DS9MiK If this sounds like you, we encourage you to apply. Know someone who’d be a strong fit? We welcome referrals! Send questions and resume applications to: hiring@lrvhealth.com

Congratulations to LRVHealth portfolio company KeyCare for securing $27.4M to scale its AI-powered, Epic-based virtual care solution for health systems. We are proud to continue supporting Sulabh Agarwal and the entire KeyCare team! Read the press release: https://lnkd.in/eRQUgf4z Read the Axios exclusive by Brock E.W. Turner: https://lnkd.in/e_hA2iAH

Congratulations to LRVHealth portfolio company Greater Good Health on announcing its Series B today! The round was led by Allumia Ventures and we participated alongside DaVita Venture Group, Granite Financial Holdings (the investment affiliate of Blue Cross of Idaho), Flare Capital Partners, Optum Ventures, Health Velocity Capital, Martin Ventures, and Epsilon Ventures. Greater Good Health is focused on expanding access to high-quality, value-based care through a nurse practitioner-centric model. As the shortage of primary care physicians continues to grow, the company is helping address the urgent need for more providers and better access to care. The results are meaningful. Today, Greater Good Health serves more than 200,000 patients through its primary care clinics and integrated clinical services platform, supporting health plans, hospital systems, and provider organizations managing complex populations in value-based arrangements. Outcomes include: - 4+ STAR quality performance - More than 200% growth in preventive care engagement - Reductions in unnecessary acute admissions - Patient Net Promoter Score above 90 The company’s first clinics launched with Humana in Montana, and in December 2025 the team opened its fourth clinic in partnership with Blue Cross of Idaho. We’re proud to continue supporting Sylvia Hastanan and the entire Greater Good Health team in this next phase of growth. Read more about the Series B announcement: - Press release: https://lnkd.in/eAP8tgwX - Axios exclusive by Brock E.W. Turner: https://lnkd.in/guA_BpEp - Interview with Health Tech Nerds: https://lnkd.in/e5pp75nj Additionally, given the impact Greater Good Health is having, we featured the company in LRVHealth’s 2025 Impact Report: https://lnkd.in/ewafhp6V

What Makes Your Artificial Intelligence or Digital Health Venture Attractive to Investors? Join our panel "AI at the Bedside: How Investors and Clinicians Turn Models Into Outcomes" with Keith J. Figlioli (LRVHealth), Parth Desai (Flare Capital Partners), and Michael Freni (Mass General Brigham Innovation). Venture capital is accelerating the leap from promising clinical AI and digital health pilots to tools that actually work at the bedside by funding validation studies, regulatory readiness, and seamless workflow integration. Join over 600 attendees from 20 countries for MESH Core to learn what it really takes to deploy safe, trusted AI in hospitals and where investors and clinicians must align to turn models into measurable patient impact. -May 4–5, 2026 -Harvard University, Boston USA Register and learn more: https://lnkd.in/eZ9dpQBd Thanks to our partners and sponsors: Harvard Medical School Professional, Corporate, and Continuing Education Crowell & Moring McGill Dobson Centre for Entrepreneurship King Saud University- Medical City King Faisal Specialist Hospital and Research Center Massachusetts Technology Collaborative Fish & Richardson P.C. #HealthcareInnovation #MESHCore #MESHCore2026 #HealthTech #MedTech Mass General Brigham Mass General Brigham Innovation

The latest episode of the #HealthcareIsHard podcast is one you won’t want to miss. Keith J. Figlioli talked to Dr. John Brownstein, Chief Innovation Officer at Boston Children's Hospital, who breaks down what it looks like as health systems move from AI pilots to real-world deployment. They touched on topics including: → Moving From pilots to production: AI adoption is happening faster than expected, even in healthcare. Health systems are scaling beyond experiments into automation, workflow support, and clinical use cases with measurable impact. → The build vs. buy shift: AI is lowering the barrier to building in-house. Startups still matter, but the bar is higher. Durable advantage now comes from proprietary data, deep workflow integration, and regulatory expertise. → The new AI architecture strategy: It’s is no longer about point solutions. Health systems are actively designing AI stacks – balancing foundation models, hyperscalers, core platforms like Epic, and targeted applications. → The culture constraint: Interest in AI is high, but so is fatigue. Adoption will depend as much on trust, communication, and workforce readiness as it does on technical capability. Listen here! https://lnkd.in/eVQQ-enQ

“Leaders must stop evaluating tools in isolation and start designing a cohesive enterprise AI architecture.” In his recent Fierce Healthcare byline, LRVHealth managing partner Keith J. Figlioli outlines why health systems and payers need to rethink how they approach AI procurement. Too often, organizations are still buying AI one tool at a time. The result is fragmentation, integration challenges, and unclear ROI. Instead, Keith points to a more durable path forward: designing a cohesive enterprise AI architecture across three layers. 1. Core infrastructure and enterprise platforms 2. Foundation model platforms 3. Specialized AI startups Healthcare AI procurement is no longer about picking tools one use case at a time. It’s about orchestrating across layers—aligning enterprise platforms, foundational capabilities, and specialized applications into a coherent system that can evolve. For startups, this shift raises the bar. It is no longer just about whether a product works, but where it fits, how it integrates, and whether it can scale. For healthcare leaders, procurement is becoming a strategic capability, not just a purchasing function. Read the full article: https://lnkd.in/e62-KE4K

The latest episode of the #HealthcareIsHard podcast dropped today. Dr. Robert Wachter, Professor and Chair of the Department of Medicine at the University of California, San Francisco joined Keith J. Figlioli for a conversation about AI and why it’s different from past waves of health IT. Dr. Wachter shared a lot of the ideas he explored in his most recent book, A Giant Leap. They covered topics like: → Why “better than today” may be the right benchmark: AI does not need to be perfect to be valuable in healthcare. If it can help clinicians review complex charts, keep up with medical literature, and reduce administrative burden better than the status quo, that is meaningful progress. → Reshaping the patient-doctor relationship: Patients are increasingly using AI to review records, understand symptoms, and shape care decisions before they ever walk into the exam room. That has implications not only for clinicians, but for how health systems think about trust, navigation, and access. → Elevating primary care: AI may allow primary care physicians to do more by offloading routine work and improving support for complex cases — while also accelerating the rise of new care models and new entrants in the market. → Underestimating the speed of change: Many leaders still do not fully appreciate how quickly AI could reshape care delivery and health system strategy. The stakes extend far beyond productivity into patient relationships, referral pathways, and long-term market position. Listen here: https://lnkd.in/e-U63b9r #HealthcareIsHard #HealthcareAI #DigitalHealth #HealthSystems #PrimaryCare #CareDelivery

One of our favorite traditions each year as Health Evolution Summit kicks off is hosting our annual reception at Chart House Dana Point. On Tuesday night, we brought together an incredible group of healthcare leaders for an evening outdoors with a beautiful view. It was a great start to the week, with thoughtful and engaging conversations throughout the night. Thank you to everyone who joined us, and to our partners Martin Ventures and Echo Health Ventures for co-hosting with us. Looking forward to next year! Devin Carty Jessica Zeaske Keith J. Figlioli Jordan Lipson Josh Flum Lise Courtney D'Amico

Earlier this week at DHIS East in Boston, Ellen Herlacher joined a panel titled “Innovating beyond the City Limits: The Future of Rural Health,” exploring the pressures facing rural providers, including workforce shortages, hospital closures, rising chronic disease, and gaps in digital infrastructure. The panel also discussed how virtual care, remote monitoring, data-driven coordination, and tech-enabled community partnerships are expanding access and helping build more sustainable models. Ellen was joined on the panel by Liana M. Douillet Guzmán (FOLX Health), Robbie Felton (IntusCare), Victor Lanio (Flare Capital Partners), and Gregory Rockson (mPharma). Thank you to the DHIS team for another great event this year! #DHISEast Cambridge Healthtech Institute

MESH Core 2026 by MESH Incubator | Mass General Brigham kicks off this morning, and Keith J. Figlioli will be leading a panel titled “Venture’s Role in Scaling Artificial Intelligence in Healthcare.” He’ll be joined by Michael Freni (Mass General Brigham) and Parth Desai (Flare Capital Partners). The discussion will cover the current state of digital health venture capital, how AI is reshaping the landscape, and what makes a company truly venture-backable today. Looking forward to being part of the event! https://lnkd.in/er-xS4JM #MESHCore2026 #HealthcareInnovation #HealthTech #Biotech #DigitalHealth #Innovation